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<puts on historian hat> "This pandemic is not an existential threat. Not having any particular ability to deal with plague is an existential threat."

ref: Neanderthals, possibly wiped out by human disease - https://www.sciencedaily.com/releases/2019/11/191107160610.htm
ref: Amerind at contact: https://en.wikipedia.org/wiki/Population_history_of_indigenous_peoples_of_the_Americas#Depopulation_from_disease